This study aimed to determine the level of anti-cyclic citrullinated peptide (ACCP), glutathione (GSH), copper (Cu) and zinc (Zn) in sera of the patients with Multiple Sclerosis (MS) and healthy subjects to examine their possible role in this disease. Thirty patients in MS were included for evaluation of serum anti-cyclic citrullinated peptide (ACCP), glutathione (GSH), copper (Cu) and zinc (Zn) and they compared with thirty normal healthy subjects. Results revealed that the serum levels of GSH and Cu were highly significant lower in MS patients than in healthy control group p< 0.005. The mean serum levels of Zn for both groups were significantly decrease p< 0.04, but the mean serum levels of ACCP in both groups were no significantly decrease p > 0.201.
Keywords: Multiple sclerosis, Anti-cyclic citrullinated peptide, Zinc and Copper.